A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development

A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development

Zebrafish is the preferred vertebrate model for high throughput chemical screens to discover modulators of complex biological pathways. We adapted a transgenic zebrafish line, Tg(dusp6:EGFP), which reports on fibroblast growth factor (Fgf)/Ras/Mapk activity, into a quantitative, high-content chemica...

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Bibliographic Details
Main Authors: Manush Saydmohammed, Laura L. Vollmer, Ezenwa O. Onuoha, Taber S. Maskrey, Gregory Gibson, Simon C. Watkins, Peter Wipf, Andreas Vogt, Michael Tsang
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
zebrafish
high-throughput screening
high-content analysis
Cognition Network Technology
Fgf signaling
heart development
probe discovery
Online Access:http://www.mdpi.com/1420-3049/23/7/1691

Internet

http://www.mdpi.com/1420-3049/23/7/1691

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