Progression of Cerebellar Atrophy in Spinocerebellar Ataxia Type 2 Gene Carriers: A Longitudinal MRI Study in Preclinical and Early Disease Stages

Progression of Cerebellar Atrophy in Spinocerebellar Ataxia Type 2 Gene Carriers: A Longitudinal MRI Study in Preclinical and Early Disease Stages

Spinocerebellar ataxias type 2 (SCA2) is an autosomal dominant inherited disease caused by expanded trinucleotide repeats (≥32 CAG) within the coding region of ATXN2 gene. Age of disease onset primarily depends on the length of the expanded region. The majority of subjects carrying the mutation rema...

Full description

Bibliographic Details
Main Authors: Anna Nigri, Lidia Sarro, Alessia Mongelli, Chiara Pinardi, Luca Porcu, Anna Castaldo, Stefania Ferraro, Marina Grisoli, Maria Grazia Bruzzone, Cinzia Gellera, Franco Taroni, Caterina Mariotti, Lorenzo Nanetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neurology
Subjects:
pre-symptomatic gene carriers
spinocerebellar ataxia (SCA2)
cerebellar lobule segmentation
cortical thickness
cognitive assessment
cerebellar structural MRI
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.616419/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2020.616419/full

Similar Items