MASM, a Matrine Derivative, Offers Radioprotection by Modulating Lethal Total-Body Irradiation-Induced Multiple Signaling Pathways in Wistar Rats

MASM, a Matrine Derivative, Offers Radioprotection by Modulating Lethal Total-Body Irradiation-Induced Multiple Signaling Pathways in Wistar Rats

Matrine is an alkaloid extracted from Sophora flavescens Ait and has many biological activities, such as anti-inflammatory, antitumor, anti-fibrosis, and immunosuppressive properties. In our previous studies, the matrine derivative MASM was synthesized and exhibited potent inhibitory activity agains...

Full description

Bibliographic Details
Main Authors: Jianzhong Li, Jing Xu, Yiming Lu, Lei Qiu, Weiheng Xu, Bin Lu, Zhenlin Hu, Zhiyong Chu, Yifeng Chai, Junping Zhang
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
MASM
radiation lethality
total-body irradiation
radioprotection
gene expression
MAPK pathways
Online Access:http://www.mdpi.com/1420-3049/21/5/649

Internet

http://www.mdpi.com/1420-3049/21/5/649

Similar Items