Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network

Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network

The Rho guanine nucleotide exchange factor (RGNEF) protein encoded by the <i>ARHGEF28</i> gene has been implicated in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Biochemical and pathological studies have shown that RGNEF is a component of the hallmark neuronal cyto...

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Bibliographic Details
Main Authors: Sonja E. Di Gregorio, Kathryn Volkening, Michael J. Strong, Martin L. Duennwald
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
RGNEF
ALS
yeast model
protein misfolding
microtubules
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/21/16/5597

Internet

https://www.mdpi.com/1422-0067/21/16/5597

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