Graves’ ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts

Graves’ ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts

ABSTRACT Objective: Graves’ ophthalmopathy (GO) is an autoimmune disease that leads to ocular proptosis caused by fat accumulation and inflammation, and the main treatment is corticosteroid therapy. Retinoid acid receptor-alpha (RARα) seems to be associated with inflammation and adipocyte different...

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Bibliographic Details
Main Authors: Sarah Santiloni Cury, Miriane Oliveira, Maria Teresa Síbio, Sueli Clara, Renata De Azevedo Melo Luvizotto, Sandro Conde, Edson Nacib Jorge, Vania dos Santos Nunes, Célia Regina Nogueira, Gláucia Maria Ferreira da Silva Mazeto
Format: Article
Language:English
Published: Brazilian Society of Endocrinology and Metabolism 2018-05-01
Series:Archives of Endocrinology and Metabolism
Subjects:
Receptors
retinoic acid
gene expression
graves ophthalmopathy
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000300366&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000300366&lng=en&tlng=en

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