Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins

Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins

Helicobacter pylori East Asian CagA is more closely associated with gastric cancer than Western CagA. Here we show that, upon tyrosine phosphorylation, the East Asian CagA-specific EPIYA-D segment binds to the N-SH2 domain of pro-oncogenic SHP2 phosphatase two orders of magnitude greater than Wester...

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Bibliographic Details
Main Authors: Takeru Hayashi, Miki Senda, Nobuhiro Suzuki, Hiroko Nishikawa, Chi Ben, Chao Tang, Lisa Nagase, Kaori Inoue, Toshiya Senda, Masanori Hatakeyama
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
Helicobacter pylori
East Asian CagA
Western CagA
SHP2
EPIYA motif
allosteric regulation
SH2 domain
gastric cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312226

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http://www.sciencedirect.com/science/article/pii/S2211124717312226

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