A Comprehensive Phenotypic and Functional Immune Analysis Unravels Circulating Anti–Phospholipase A2 Receptor Antibody Secreting Cells in Membranous Nephropathy Patients

A Comprehensive Phenotypic and Functional Immune Analysis Unravels Circulating Anti–Phospholipase A2 Receptor Antibody Secreting Cells in Membranous Nephropathy Patients

Introduction: Primary membranous nephropathy (MN) is characterized by the presence of antipodocyte antibodies, but studies describing phenotypic and functional abnormalities in circulating lymphocytes are limited. Methods: We analyzed 68 different B- and T-cell subsets using flow cytometry in 30 MN...

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Bibliographic Details
Main Authors: Chiara Cantarelli, Marta Jarque, Andrea Angeletti, Joaquin Manrique, Susan Hartzell, Timothy O’Donnell, Elliot Merritt, Uri Laserson, Laura Perin, Chiara Donadei, Lisa Anderson, Clara Fischman, Emilie Chan, Juliana Draibe, Xavier Fulladosa, Joan Torras, Leonardo V. Riella, Gaetano La Manna, Enrico Fiaccadori, Umberto Maggiore, Oriol Bestard, Paolo Cravedi
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Kidney International Reports
Subjects:
membranous nephropathy
phospholipase A2 receptor
plasma cells
regulatory B cells
regulatory T cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024920314273

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http://www.sciencedirect.com/science/article/pii/S2468024920314273

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