The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.

The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.

IMPACT, a highly conserved protein, is an inhibitor of the eIF2α kinase GCN2. In mammals, it is preferentially expressed in neurons. Knock-down of IMPACT expression in neuronal cells increases basal GCN2 activation and eIF2α phosphorylation and decreases translation initiation. In the mouse brain, I...

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Bibliographic Details
Main Authors: Catia M Pereira, Renato Filev, Francisco P Dubiela, Bruna B Brandão, Claudio M Queiroz, Raissa G Ludwig, Debora Hipolide, Beatriz M Longo, Luiz E Mello, Marcelo A Mori, Beatriz A Castilho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0217287

Internet

https://doi.org/10.1371/journal.pone.0217287

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