Histone Deacetylase Inhibitors Increase p27Kip1 by Affecting Its Ubiquitin-Dependent Degradation through Skp2 Downregulation

Histone Deacetylase Inhibitors Increase p27Kip1 by Affecting Its Ubiquitin-Dependent Degradation through Skp2 Downregulation

Histone deacetylase inhibitors (HDACIs) represent an intriguing class of pharmacologically active compounds. Currently, some HDACIs are FDA approved for cancer therapy and many others are in clinical trials, showing important clinical activities at well tolerated doses. HDACIs also interfere with th...

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Bibliographic Details
Main Authors: Adriana Borriello, Silvio Naviglio, Debora Bencivenga, Ilaria Caldarelli, Annunziata Tramontano, Maria Carmela Speranza, Emanuela Stampone, Luigi Sapio, Aide Negri, Adriana Oliva, Antonio Agostino Sinisi, Annamaria Spina, Fulvio Della Ragione
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2016/2481865

Internet

http://dx.doi.org/10.1155/2016/2481865

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