A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA[S]

A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA[S]

Saturated free fatty acids (FFA) induce hepatocyte lipoapoptosis, a key mediator of liver injury in nonalcoholic fatty liver disease (NAFLD). Lipoapoptosis involves the upregulation of the BH3-only protein PUMA, a potent pro-apoptotic protein. Given that dysregulation of hepatic microRNA expression...

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Bibliographic Details
Main Authors: Sophie C. Cazanave, Justin L. Mott, Nafisa A. Elmi, Steven F. Bronk, Howard C. Masuoka, Michael R. Charlton, Gregory J. Gores
Format: Article
Language:English
Published: Elsevier 2011-08-01
Series:Journal of Lipid Research
Subjects:
BH3-only proteins
free fatty acid
hepatic steatosis
microRNA
p53-upregulated mediator of apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520369273

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520369273

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