Local Antigen Encounter Is Essential for Establishing Persistent CD8+ T-Cell Memory in the CNS

Local Antigen Encounter Is Essential for Establishing Persistent CD8+ T-Cell Memory in the CNS

While the brain is considered an immune-privileged site, the CNS may nevertheless be the focus of immune mediated inflammation in the case of infection and certain autoimmune diseases, e.g., multiple sclerosis. As in other tissues, it has been found that acute T-cell infiltration may be followed by...

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Bibliographic Details
Main Authors: Amalie S. Schøller, Masja Fonnes, Loulieta Nazerai, Jan P. Christensen, Allan R. Thomsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
immune surveillance
CNS
tissue resident memory T cells
adenovectors
viral infection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00351/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00351/full

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