A Role for the VPS Retromer in Brucella Intracellular Replication Revealed by Genomewide siRNA Screening

A Role for the VPS Retromer in Brucella Intracellular Replication Revealed by Genomewide siRNA Screening

With >300,000 new cases of human brucellosis annually, Brucella is regarded as one of the most important zoonotic bacterial pathogens worldwide. The agent causing brucellosis resides inside host cells within vacuoles termed Brucella-containing vacuoles (BCVs). Although a few host components requi...

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Bibliographic Details
Main Authors: Alain Casanova, Shyan Huey Low, Maxime Québatte, Jaroslaw Sedzicki, Therese Tschon, Maren Ketterer, Kevin Smith, Mario Emmenlauer, Houchaima Ben-Tekaya, Christoph Dehio
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mSphere
Subjects:
Brucella
RAB7A
VPS retromer
VPS26
VPS35
replicative niche
siRNA
Online Access:https://doi.org/10.1128/mSphere.00380-19

Internet

https://doi.org/10.1128/mSphere.00380-19

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