Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor

Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor

The adoptive transfer of chimeric antigen receptor-T (CAR-T) cells has shown remarkable clinical responses in hematologic malignancies. However, unsatisfactory curative results and side effects for tumor treatment are still unsolved problems. Herein we develop a click CAR-T cell engineering strategy...

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Bibliographic Details
Main Authors: Hong Pan, Wenjun Li, Ze Chen, Yingmei Luo, Wei He, Mengmeng Wang, Xiaofan Tang, Huamei He, Lanlan Liu, Mingbin Zheng, Xin Jiang, Ting Yin, Ruijing Liang, Yifan Ma, Lintao Cai
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-04-01
Series:Bioactive Materials
Subjects:
CAR-T cell
Bioorthogonal click chemistry
Glycometabolic labeling
Off-target effects
Cell immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X20302450

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X20302450

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