Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage

Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage

Holliday junctions (HJs) are key DNA intermediates in homologous recombination. They link homologous DNA strands and have to be faithfully removed for proper DNA segregation and genome integrity. Here, we present the crystal structure of human HJ resolvase GEN1 complexed with DNA at 3.0 Å resolution...

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Bibliographic Details
Main Authors: Shun-Hsiao Lee, Lissa Nicola Princz, Maren Felizitas Klügel, Bianca Habermann, Boris Pfander, Christian Biertümpfel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
Holliday junction resolvase
GEN1
chromodomain
crystal structure
protein-DNA complex
Yen1
Online Access:https://elifesciences.org/articles/12256

Internet

https://elifesciences.org/articles/12256

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