Preclinical pharmacokinetics, tissue distribution and plasma protein binding of sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate (BZP), an innovative potent anti-ischemic stroke agent

Preclinical pharmacokinetics, tissue distribution and plasma protein binding of sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate (BZP), an innovative potent anti-ischemic stroke agent

Sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate (BZP) is a potential cardiovascular drug and exerts potent neuroprotective effect against transient and long-term ischemic stroke in rats. BZP could convert into 3-butyl-6-bromo-1(3H)-isobenzofuranone (Br-NBP) in vitro and in vivo. However, the pharmac...

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Bibliographic Details
Main Authors: Xin Tian, Hongmeng Li, Jingyao Wei, Bingjie Liu, Yuhai Zhang, Gaoju Wang, Junbiao Chang, Hailing Qiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Pharmacology
Subjects:
Tissue Distribution
pharmacokinetics
metabolite
Plasma protein binding
BzP
Br-NBP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00255/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00255/full

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