De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects

De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects

Abstract Transient receptor potential vanilloid 1 (TRPV1) ion channel is a nociceptor critically involved in pain sensation. Direct blockade of TRPV1 exhibits significant analgesic effects but also incurs severe side effects such as hyperthermia, causing failures of TRPV1 inhibitors in clinical tria...

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Bibliographic Details
Main Authors: Lizhen Xu, Heng Zhang, Yunfei Wang, Xiancui Lu, Zhenye Zhao, Cheng Ma, Shilong Yang, Vladimir Yarov‐Yarovoy, Yuhua Tian, Jie Zheng, Fan Yang
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Advanced Science
Subjects:
ion channel
pain
positive allosteric modulator
protein design
TRPV1
Online Access:https://doi.org/10.1002/advs.202101716

Internet

https://doi.org/10.1002/advs.202101716

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