5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT

Recent studies have shown that endogenous serotonin is not required for colonic peristalsis in vitro, nor gastrointestinal (GI) transit in vivo. However, antagonists of 5-Hydroxytryptamine (5-HT) receptors can inhibit peristalsis and GI-transit in mammals, including humans. This raises the question...

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Bibliographic Details
Main Authors: Tiong Cheng Sia, Malcolm eWhiting, Melinda eKyloh, Sarah eNicholas, Simon J Brookes, John eOliver, Phil eDinning, David A Wattchow, Nick J Spencer
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Neuroscience
Subjects:
Colon
Peristalsis
Serotonin Antagonists
motility
transit
peristaltic reflex
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00136/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00136/full

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