Differential effects of exposure to maternal obesity or maternal weight loss during the periconceptional period in the sheep on insulin signalling molecules in skeletal muscle of the offspring at 4 months of age.

Differential effects of exposure to maternal obesity or maternal weight loss during the periconceptional period in the sheep on insulin signalling molecules in skeletal muscle of the offspring at 4 months of age.

Exposure to maternal obesity before and/or throughout pregnancy may increase the risk of obesity and insulin resistance in the offspring in childhood and adult life, therefore, resulting in its transmission into subsequent generations. We have previously shown that exposure to maternal obesity aroun...

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Bibliographic Details
Main Authors: Lisa M Nicholas, Janna L Morrison, Leewen Rattanatray, Susan E Ozanne, Dave O Kleemann, Simon K Walker, Severence M MacLaughlin, Song Zhang, Malgorzata S Martin-Gronert, Isabella C McMillen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3873457?pdf=render

Internet

http://europepmc.org/articles/PMC3873457?pdf=render

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