Embelin, a Potent Molecule for Alzheimer's Disease: A Proof of Concept From Blood-Brain Barrier Permeability, Acetylcholinesterase Inhibition and Molecular Docking Studies

Embelin, a Potent Molecule for Alzheimer's Disease: A Proof of Concept From Blood-Brain Barrier Permeability, Acetylcholinesterase Inhibition and Molecular Docking Studies

Embelin is well-known in ethnomedicine and reported to have central nervous system activities. However, there is no report on blood-brain barrier (BBB) permeability of embelin. Here the BBB permeability of embelin was evaluated using in vitro primary porcine brain endothelial cell (PBEC) model of th...

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Bibliographic Details
Main Authors: Saatheeyavaane Bhuvanendran, Nur Aziah Hanapi, Nafees Ahemad, Iekhsan Othman, Siti Rafidah Yusof, Mohd Farooq Shaikh
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Neuroscience
Subjects:
embelin
blood-brain barrier
permeability
acetylcholinesterase inhibitor
molecular docking
amyloid beta peptides
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00495/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00495/full

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