Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

Alzheimer’s disease (AD) is a large and increasing unmet medical need with no disease-modifying treatment currently available. Genetic evidence from genome-wide association studies (GWASs) and gene network analysis has clearly revealed a key role of the innate immune system in the brain, of which mi...

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Bibliographic Details
Main Authors: Knut Biber, Anindya Bhattacharya, Brian M. Campbell, Justin R. Piro, Michael Rohe, Roland G.W. Staal, Robert V. Talanian, Thomas Möller
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
drug target
microglia
target identification
target validation
screening cascade
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00840/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00840/full

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