Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity

Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity

Fibroblast growth factor 1 (FGF1) has been shown to interact with integrin &#945;<sub>v</sub>&#946;<sub>3</sub> through a specific binding site, involving Arg35 residue. The FGF1 mutant (R35E) with impaired integrin binding was found to be defective in its proliferati...

Full description

Bibliographic Details
Main Authors: Anna Szlachcic, Martyna Sochacka, Aleksandra Czyrek, Lukasz Opalinski, Daniel Krowarsch, Jacek Otlewski, Malgorzata Zakrzewska
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
fibroblast growth factor 1
integrin α<sub>v</sub>β<sub>3</sub>
protein stability
proteolytic degradation
mitogenic activity
protein-protein interaction
anti-apoptotic activity
Online Access:https://www.mdpi.com/2073-4409/8/8/899

Internet

https://www.mdpi.com/2073-4409/8/8/899

Similar Items