Natural IgM and TLR Agonists Switch Murine Splenic Pan-B to “Regulatory” Cells That Suppress Ischemia-Induced Innate Inflammation via Regulating NKT-1 Cells

Natural IgM and TLR Agonists Switch Murine Splenic Pan-B to “Regulatory” Cells That Suppress Ischemia-Induced Innate Inflammation via Regulating NKT-1 Cells

Natural IgM anti-leukocyte autoantibodies (IgM-ALAs) inhibit inflammation by several mechanisms. Here, we show that pan-B cells and bone marrow-derived dendritic cells (BMDCs) are switched to regulatory cells when pretreated ex vivo with IgM. B cells are also switched to regulatory cells when pretre...

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Bibliographic Details
Main Authors: Peter I. Lobo, Kailo H. Schlegel, Amandeep Bajwa, Liping Huang, Mark D. Okusa
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
natural IgM
IgM anti-leukocyte antibodies
Bregs
CpG
innate inflammation
ischemia–reperfusion injury
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00974/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00974/full

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