Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4+ T-Cells.

Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4+ T-Cells.

BACKGROUND:Little is known about the expression of inhibitory molecules cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed-death-1 (PD-1) on Mycobacterium tuberculosis (Mtb)-specific CD4 T-cells and how their expression is impacted by TB treatment. METHODS:Cryopreserved PBMCs from HIV-TB co-in...

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Bibliographic Details
Main Authors: Kapil K Saharia, Constantinos Petrovas, Sara Ferrando-Martinez, Manuel Leal, Rafael Luque, Prudence Ive, Anne Luetkemeyer, Diane Havlir, Richard A Koup
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4930205?pdf=render

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http://europepmc.org/articles/PMC4930205?pdf=render

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