Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4+ T-Cells.
BACKGROUND:Little is known about the expression of inhibitory molecules cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed-death-1 (PD-1) on Mycobacterium tuberculosis (Mtb)-specific CD4 T-cells and how their expression is impacted by TB treatment. METHODS:Cryopreserved PBMCs from HIV-TB co-in...
Main Authors: | Kapil K Saharia, Constantinos Petrovas, Sara Ferrando-Martinez, Manuel Leal, Rafael Luque, Prudence Ive, Anne Luetkemeyer, Diane Havlir, Richard A Koup |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4930205?pdf=render |
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