The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

Overall survival for patients with ovarian cancer (OC) has shown little improvement for decades meaning new therapeutic options are critical. OC comprises multiple histological subtypes, of which the most common and aggressive subtype is high-grade serous ovarian cancer (HGSOC). HGSOC is characteriz...

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Bibliographic Details
Main Authors: Shunfei Yan, Daniel Frank, Jinbae Son, Katherine M. Hannan, Ross D. Hannan, Keefe T. Chan, Richard B. Pearson, Elaine Sanij
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
high-grade serous carcinoma
ribosome biogenesis
Pol I
CX-5461
homologous recombination
Online Access:http://www.mdpi.com/1422-0067/18/1/210

Internet

http://www.mdpi.com/1422-0067/18/1/210

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