Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest genetic association is with HLA-DQA1*04:01, but at least three additional independent HLA haplotypes contribute to susceptibility. We used dense...

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Bibliographic Details
Main Authors: Rebecca Darlay, Kristin L Ayers, George F Mells, Lynsey S Hall, Jimmy Z Liu, Mohamed A Almarri, Graeme J Alexander, David E Jones, Richard N Sandford, Carl A Anderson, Heather J Cordell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007833

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https://doi.org/10.1371/journal.pgen.1007833

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