Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats

Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats

Abstract Background Microglia, the principal sentinel immune cells of the central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND). Histamine, a potent mediator of inflammation, can both promote and prevent microglia-related n...

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Bibliographic Details
Main Authors: Yi-Nan Chen, Huan-Huan Sha, Yi-Wei Wang, Qin Zhou, Piplu Bhuiyan, Na-Na Li, Yan-Ning Qian, Hong-Quan Dong
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Histamine receptors
Perioperative neurocognitive disorders
Inflammatory factors
TLR4
FoxO1
Online Access:http://link.springer.com/article/10.1186/s12974-020-01886-2

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http://link.springer.com/article/10.1186/s12974-020-01886-2

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