REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment
Bryostatin 1 (henceforth bryostatin) is in clinical trials for the treatment of Alzheimer’s disease and for HIV/AIDS eradication. It is also a preclinical lead for cancer immunotherapy and other therapeutic indications. Yet nothing is known about the conformation of bryostatin bound to its protein k...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2018-01-01
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| Series: | ACS Central Science |
| Online Access: | http://dx.doi.org/10.1021/acscentsci.7b00475 |