Plasmid-based generation of induced neural stem cells from adult human fibroblasts

Plasmid-based generation of induced neural stem cells from adult human fibroblasts

Direct reprogramming from somatic to neural cell types has become an alternative to induced pluripotent stem cells. Most protocols employ viral expression systems, posing the risk of random genomic integration. Recent developments led to plasmid-based protocols, lowering this risk. However, these pr...

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Bibliographic Details
Main Authors: Philipp Capetian, Luis Azmitia, Martje Gesine Pauly, Victor Krajka, Felix Stengel, Eva-Maria Bernhardi, Mariana Klett, Britta Meier, Philip Seibler, Nancy Stanslowsky, Andreas Moser, Andreas Knopp, Gabriele Gillessen-Kaesbach, Guido Nikkhah, Florian Wegner, Màté Dániel Döbrössy, Christine Klein
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neurophysiology
Direct reprogramming
Induced neural stem cells
plasmid based reprogramming
adult human fibroblasts
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00245/full

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http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00245/full

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