Occurrence of High Microsatellite-Instability/Mismatch Repair Deficiency in Nearly 2,000 Human Adenocarcinomas of the Gastrointestinal Tract, Pancreas, and Bile Ducts: A Study From a Large German Comprehensive Cancer Center

Occurrence of High Microsatellite-Instability/Mismatch Repair Deficiency in Nearly 2,000 Human Adenocarcinomas of the Gastrointestinal Tract, Pancreas, and Bile Ducts: A Study From a Large German Comprehensive Cancer Center

IntroductionKnowledge of the high microsatellite-instability (MSI-H)/mismatch repair deficiency (MMRd) status is of increasing interest for personalized neoadjuvant or adjuvant therapy planning. Only a few studies are available on MSI-H distribution in the Northern European Caucasian patient populat...

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Main Authors: Alexander Quaas, Jan Rehkaemper, Josef Rueschoff, Aylin Pamuk, Thomas Zander, Axel Hillmer, Janna Siemanowski, Jana Wittig, Reinhard Buettner, Patrick Plum, Felix Popp, Florian Gebauer, Christiane Josephine Bruns, Heike Loeser, Hakan Alakus, Birgid Schoemig-Markiefka
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
Union for International Cancer Control (UICC) stage 4
esophageal adenocarcinoma
gastric carcinoma
high microsatellite-instability (MSI-H)
microsatellite-instability
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.569475/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.569475/full

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