DNA Methylation in the Diagnosis of Monogenic Diseases

DNA Methylation in the Diagnosis of Monogenic Diseases

DNA methylation in the human genome is largely programmed and shaped by transcription factor binding and interaction between DNA methyltransferases and histone marks during gamete and embryo development. Normal methylation profiles can be modified at single or multiple loci, more frequently as conse...

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Bibliographic Details
Main Authors:	Flavia Cerrato, Angela Sparago, Francesca Ariani, Fulvia Brugnoletti, Luciano Calzari, Fabio Coppedè, Alessandro De Luca, Cristina Gervasini, Emiliano Giardina, Fiorella Gurrieri, Cristiana Lo Nigro, Giuseppe Merla, Monica Miozzo, Silvia Russo, Eugenio Sangiorgi, Silvia M Sirchia, Gabriella Maria Squeo, Silvia Tabano, Elisabetta Tabolacci, Isabella Torrente, Maurizio Genuardi, Giovanni Neri, Andrea Riccio
Format:	Article
Language:	English
Published:	MDPI AG 2020-03-01
Series:	Genes
Subjects:	dna methylation genetic testing high-throughput analysis epi-signatures developmental delay/intellectual disability disorders imprinting disorders hereditary tumors neuromuscular diseases prenatal diagnosis
Online Access:	https://www.mdpi.com/2073-4425/11/4/355

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