Quantification of hTERT Splice Variants in Melanoma by SYBR Green Real-time Polymerase Chain Reaction Indicates a Negative Regulatory Role for the β Deletion Variant

Quantification of hTERT Splice Variants in Melanoma by SYBR Green Real-time Polymerase Chain Reaction Indicates a Negative Regulatory Role for the β Deletion Variant

Telomerase activity is primarily determined by transcriptional regulation of the catalytic subunit, human telomerase reverse transcriptase (hTERT). Several mRNA splice variants for hTERT have been identified, but it is not clear if telomerase activity is determined by the absolute or relative level...

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Bibliographic Details
Main Authors: Lisa F. Lincz, Lisa-Maree Mudge, Fiona E. Scorgie, Jennette A. Sakoff, Christopher S. Hamilton, Michael Seldon
Format: Article
Language:English
Published: Elsevier 2008-10-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608801030

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http://www.sciencedirect.com/science/article/pii/S1476558608801030

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