Influence of Lipid A Acylation Pattern on Membrane Permeability and Innate Immune Stimulation

Lipid A, the hydrophobic anchor of lipopolysaccharide (LPS), is an essential component in the outer membrane of Gram-negative bacteria. It can stimulate the innate immune system via Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD2), leading to the release of inflammatory cytokines. In...

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Bibliographic Details
Main Authors: Robert K. Ernst, Xiaoyuan Wang, Jiuzhou Chen, Zhou Wang, Yanyan Li
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Marine Drugs
Subjects:
Online Access:http://www.mdpi.com/1660-3397/11/9/3197