Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides

Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides

Aim: Aging and heart failure (HF) are each characterized by increased mitochondrial damage, which may contribute to further cardiac dysfunction. Mitophagy in response to mitochondrial damage can improve cardiovascular health. HF is also characterized by increased formation and consumption of ketone...

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Bibliographic Details
Main Authors: Phung N. Thai, Lea K. Seidlmayer, Charles Miller, Maura Ferrero, Gerald W. Dorn, Saul Schaefer, Donald M. Bers, Elena N. Dedkova
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Physiology
Subjects:
heart failure
aging
ketone bodies
β-hydroxybutyrate
mitophagy
mitofusin
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00382/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00382/full

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