Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the Poorly Water Soluble Drug Indomethacin: In Vitro and In Vivo

Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the Poorly Water Soluble Drug Indomethacin: In Vitro and In Vivo

This work explored absorption efficacy via an in vivo imaging system and parallel artificial membrane penetration in indomethacin (IMC) solid dispersion (SD) systems. Two different polymer excipients—hydroxypropyl methylcellulose (HPMC) and Kollicoat IR as precipitation inhibitors (PIs)&am...

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Bibliographic Details
Main Authors: Ziyue Xi, Wei Zhang, Yali Fei, Mingshu Cui, Luyao Xie, Lu Chen, Lu Xu
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceutics
Subjects:
indomethacin
solid dispersion
mesoporous silica nanoparticles
solubility
bioavailability
Online Access:https://www.mdpi.com/1999-4923/12/2/144

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https://www.mdpi.com/1999-4923/12/2/144

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