<it>Mycobacterium tuberculosis</it>-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways

<it>Mycobacterium tuberculosis</it>-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways

<p>Abstract</p> <p>Tuberculosis (TB) of the central nervous system (CNS) is a deadly disease characterized by extensive tissue destruction, driven by molecules such as Matrix Metalloproteinase-2 (MMP-2) which targets CNS-specific substrates. In a simplified cellular model of CNS TB...

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Bibliographic Details
Main Authors: Elkington Paul T, Fry Julie, Moores Rachel, Ong Catherine WM, Janczar Karolina, Dholakia Shruti, Green Justin A, Roncaroli Federico, Friedland Jon S
Format: Article
Language:English
Published: BMC 2011-05-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/8/1/46

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http://www.jneuroinflammation.com/content/8/1/46

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