Mechanisms of T-Cell Exhaustion in Pancreatic Cancer

Mechanisms of T-Cell Exhaustion in Pancreatic Cancer

T-cell exhaustion is a phenomenon that represents the dysfunctional state of T cells in chronic infections and cancer and is closely associated with poor prognosis in many cancers. The endogenous T-cell immunity and genetically edited cell therapies (CAR-T) failed to prevent tumor immune evasion. Th...

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Bibliographic Details
Main Authors: Didem Saka, Muazzez Gökalp, Betül Piyade, Nedim Can Cevik, Elif Arik Sever, Derya Unutmaz, Güralp O. Ceyhan, Ihsan Ekin Demir, Hande Asimgil
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
PDAC
T-cell exhaustion
epigenetics
Thymocyte selection-associated high mobility group box protein
TOXs
Online Access:https://www.mdpi.com/2072-6694/12/8/2274

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https://www.mdpi.com/2072-6694/12/8/2274

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