Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex

Bacterial DNA gyrase is the only type II DNA topoisomerase capable of introducing negative supercoils into DNA and is of interest as a drug target. Here the authors present the cryo-EM structure of the complete E. coli DNA gyrase bound to a 180 bp double-stranded DNA and the antibiotic gepotidacin,...

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Bibliographic Details
Main Authors: Arnaud Vanden Broeck, Christophe Lotz, Julio Ortiz, Valérie Lamour
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12914-y