Negative Correlation between Circulating CD4+FOXP3+CD127− Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria–Tetanus–Pertussis Vaccine Implies a Regulatory Role

Negative Correlation between Circulating CD4+FOXP3+CD127− Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria–Tetanus–Pertussis Vaccine Implies a Regulatory Role

Regulatory T cells (Tregs) play a key homeostatic role by suppressing immune responses. They have been targeted in mouse and human cancer studies to improve vaccine immunogenicity and tumor clearance. A number of commercially available drugs and experimental vaccine adjuvants have been shown to targ...

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Bibliographic Details
Main Authors: Jorjoh Ndure, Fatou Noho-Konteh, Jane U. Adetifa, Momodou Cox, Francis Barker, My Thanh Le, Lady C. Sanyang, Adboulie Drammeh, Hilton C. Whittle, Ed Clarke, Magdalena Plebanski, Sarah L. Rowland-Jones, Katie L. Flanagan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
vaccines
regulatory T cells
sex
beta-2 microglobulin
cytokines
immune activation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00921/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00921/full

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