Intracellular calcium release through IP3R or RyR contributes to secondary axonal degeneration

Intracellular calcium release through IP3R or RyR contributes to secondary axonal degeneration

Severed CNS axons often retract or dieback away from the injury site and fail to regenerate. The precise mechanisms underlying acute axonal dieback and secondary axonal degeneration remain poorly understood. Here we investigate the role of Ca2+ store mediated intra-axonal Ca2+ release in acute axona...

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Bibliographic Details
Main Authors: Ben C. Orem, Nicolas Pelisch, Joshua Williams, Jacqueline M. Nally, David P. Stirling
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Neurobiology of Disease
Subjects:
Axonal retraction
Ryanodine receptor
IP3 receptor
Spinal cord injury
Two-photon excitation microscopy
Axonal dieback
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611730164X

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http://www.sciencedirect.com/science/article/pii/S096999611730164X

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