Overexpression of MYCT1 Inhibits Proliferation and Induces Apoptosis in Human Acute Myeloid Leukemia HL-60 and KG-1a Cells in vitro and in vivo

Overexpression of MYCT1 Inhibits Proliferation and Induces Apoptosis in Human Acute Myeloid Leukemia HL-60 and KG-1a Cells in vitro and in vivo

MYC target 1 (MYCT1), a direct target gene of c-Myc, is a novel candidate tumor suppressor gene first cloned from laryngeal squamous cell carcinoma. The downregulation of MYCT1 has been reported to be associated with carcinogenesis. However, the role of MYCT1 in the development and progress of acute...

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Bibliographic Details
Main Authors: Shuang Fu, Yu Fu, Fang Chen, Yanping Hu, Bi Quan, Jihong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
acute myeloid leukemia
MYC target 1
cell cycle arrest
proliferation
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01045/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01045/full

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