Overexpression of MYCT1 Inhibits Proliferation and Induces Apoptosis in Human Acute Myeloid Leukemia HL-60 and KG-1a Cells in vitro and in vivo
MYC target 1 (MYCT1), a direct target gene of c-Myc, is a novel candidate tumor suppressor gene first cloned from laryngeal squamous cell carcinoma. The downregulation of MYCT1 has been reported to be associated with carcinogenesis. However, the role of MYCT1 in the development and progress of acute...
Main Authors: | Shuang Fu, Yu Fu, Fang Chen, Yanping Hu, Bi Quan, Jihong Zhang |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-09-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01045/full |
Similar Items
-
Overexpression of PRDM5 promotes acute myeloid leukemia cell proliferation and migration by activating the JNK pathway
by: Pan Zhou, et al.
Published: (2019-07-01) -
Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia
by: Bhuwan Giri, et al.
Published: (2019-05-01) -
The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
by: Raffaella Pippa, et al.
Published: (2020-02-01) -
Chemoresponse of de novo Acute Myeloid Leukemia to “7+3” Induction can Be Predicted by c-Myc-facilitated Cytogenetics
by: Tzu-Hung Hsiao, et al.
Published: (2021-04-01) -
Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells
by: Huang Q, et al.
Published: (2019-06-01)