Fragment Enrichment of Circulating Tumor DNA With Low-Frequency Mutations

Fragment Enrichment of Circulating Tumor DNA With Low-Frequency Mutations

Human blood contains cell-free DNA (cfDNA), with circulating tumor-derived DNAs (ctDNAs) widely used in cancer diagnosis and treatment. However, it is still difficult to efficiently and accurately identify and distinguish specific ctDNAs from normal cfDNA in cancer patient blood samples. In this stu...

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Bibliographic Details
Main Authors: Xiaojun Liu, Jidong Lang, Shijun Li, Yuehua Wang, Lihong Peng, Weitao Wang, Yingmin Han, Cuixiao Qi, Lei Song, Shuangshuang Yang, Kaixin Zhang, Guoliang Zang, Hong Pei, Qingqing Lu, Yonggang Peng, Shuxue Xi, Weiwei Wang, Dawei Yuan, Pingping Bing, Liqian Zhou, Geng Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Genetics
Subjects:
low-frequency tumor mutation
cell-free DNA
circulating tumor-derived DNA
fragment length enrichment
mutant allele frequency
next generation sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00147/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00147/full

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