The tumor suppressor p53 can promote collective cellular migration.

The tumor suppressor p53 can promote collective cellular migration.

Loss of function of the tumor suppressor p53 is known to increase the rate of migration of cells transiting the narrow pores of the traditional Boyden chamber assay. Here by contrast we investigate how p53 impacts the rate of cellular migration within a 2D confluent cell layer and a 3D collagen-embe...

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Bibliographic Details
Main Authors: Shijie He, Christopher V Carman, Jung Hyun Lee, Bo Lan, Stephan Koehler, Lior Atia, Chan Young Park, Jae Hun Kim, Jennifer A Mitchel, Jin-Ah Park, James P Butler, Quan Lu, Jeffrey J Fredberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0202065

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https://doi.org/10.1371/journal.pone.0202065

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