Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes

Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes

Previous studies had shown that the integration of genome wide expression profiles, in metabolic tissues, with genetic and phenotypic variance, provided valuable insight into the underlying molecular mechanisms. We used RNA-Seq to characterize hypothalamic transcriptome in 99 inbred strains of mice...

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Bibliographic Details
Main Authors: Yehudit Hasin-Brumshtein, Arshad H Khan, Farhad Hormozdiari, Calvin Pan, Brian W Parks, Vladislav A Petyuk, Paul D Piehowski, Anneke Brümmer, Matteo Pellegrini, Xinshu Xiao, Eleazar Eskin, Richard D Smith, Aldons J Lusis, Desmond J Smith
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
RNA-Seq
trans-eQTL
hypothalamus
high fat diet
obesity
eQTL
Online Access:https://elifesciences.org/articles/15614

Internet

https://elifesciences.org/articles/15614

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