Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip

Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip

Abstract EGFR mutations companion diagnostics have been proved to be crucial for the efficacy of tyrosine kinase inhibitor targeted cancer therapies. To uncover multiple mutations occurred in minority of EGFR-mutated cells, which may be covered by the noises from majority of un-mutated cells, is cur...

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Bibliographic Details
Main Authors: Ren Li, Mingxing Zhou, Jine Li, Zihua Wang, Weikai Zhang, Chunyan Yue, Yan Ma, Hailin Peng, Zewen Wei, Zhiyuan Hu
Format: Article
Language:English
Published: SpringerOpen 2017-11-01
Series:Nano-Micro Letters
Subjects:
EGFR mutation
Single-cell analysis
Microfluidic chip
Tyrosine kinase inhibitor
Online Access:http://link.springer.com/article/10.1007/s40820-017-0168-y

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http://link.springer.com/article/10.1007/s40820-017-0168-y

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