Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank

Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank

Homozygosity for the SERPINA1 Z allele causes α1-antitrypsin deficiency, a rare condition that can cause lung and liver disease. However, the effects of Z allele heterozygosity on nonrespiratory phenotypes, and on lung function in the general population, remain unclear. We conducted a large, populat...

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Bibliographic Details
Main Authors: Katherine A. Fawcett, Kijoung Song, Guoqing Qian, Aliki-Eleni Farmaki, Richard Packer, Catherine John, Nick Shrine, Raquel Granell, Sue Ring, Nicholas J. Timpson, Laura M. Yerges-Armstrong, Richard Eastell, Louise V. Wain, Robert A. Scott, Martin D. Tobin, Ian P. Hall
Format: Article
Language:English
Published: European Respiratory Society 2021-05-01
Series:ERJ Open Research
Online Access:http://openres.ersjournals.com/content/7/2/00049-2021.full

Internet

http://openres.ersjournals.com/content/7/2/00049-2021.full

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