Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome

Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome

Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 receptor subtype, however there is no clinical evidence of a D3 receptor dysfunction in RLS patients. In contrast, genome-wide association studies in RLS patients have establi...

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Bibliographic Details
Main Authors: Samantha Meneely, Mai-Lynne Dinkins, Miki Kassai, Shangru Lyu, Yuning Liu, Chien-Te Lin, Kori Brewer, Yuqing Li, Stefan Clemens
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
RLS animal models
dopamine
D1 receptor
D3 receptor
Meis1
sensorimotor function
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00199/full

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https://www.frontiersin.org/article/10.3389/fnbeh.2018.00199/full

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