MRAP2 regulates ghrelin receptor signaling and hunger sensing

Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling. Here the authors show that MRAP2 also regulates ghrelin receptor signalling in the hypothalamus and starvation sensing in mice.

Bibliographic Details
Main Authors: Dollada Srisai, Terry C. Yin, Abigail A. Lee, Alix A. J. Rouault, Nicole A. Pearson, Justin L. Grobe, Julien A. Sebag
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00747-6