Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells

Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells

Abstract Background Phthiocerol dimycocerosates (PDIM), glycolipids found on the outer surface of virulent members of the Mycobacterium tuberculosis (Mtb) complex, are a major contributing factor to the pathogenesis of Mtb. Myelocytic cells, such as macrophages and dendritic cells, are the primary h...

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Bibliographic Details
Main Authors: Thomas R. Lerner, Christophe J. Queval, Antony Fearns, Urska Repnik, Gareth Griffiths, Maximiliano G. Gutierrez
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Biology
Subjects:
Mycobacterium tuberculosis
Tuberculosis
Phthiocerol dimycocerosates
PDIM
Lymphatic endothelial cells
hLEC
Online Access:http://link.springer.com/article/10.1186/s12915-017-0471-6

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http://link.springer.com/article/10.1186/s12915-017-0471-6

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